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Background: Diabetes Mellitus (DM) triggers an too much response of cost-free-radicals. It will increase reactive oxygen species and lowers antioxidants status as well as the β mobile problems. Obvious kefir was used for DM therapies, however it confined biomolecular exploration of its bioactive roles. Exploration aimed to research the effects of crystal clear kefir within the biomolecular nature with the glycemic status of T2DM in Bandung. Solutions: The randomized pretest-posttest Management team was performed by 106 T2DM people. Study was performed in numerous hospitals in Bandung and Cimahi, West Java from 2012–2013. Samples were being divided randomly into three groups: (one) T2DM with HbA1c < 7 was fed a typical food plan, supplemented with 200 ml/day of crystal clear kefir, (two) T2DM with HbA1c > 7 fed common food plan and supplemented 200 ml/day by crystal clear kefir, (three) T2DM with HbA1c was fed a typical diet regime to be a Handle team.